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Upon discovering the talented Dr. Killebrew in the early 2000s, Nathaniel Essex and his compatriot Dr. Hudson created the 'Hospice' facility on the outskirts of Vancouver, B.C. Under the guise of offering experimental medical therapy to the chronically ill, Dr. Killebrew and his associate Francis Fanny performed radical gene therapies in an attempt to trigger a metagene crisis. Hospice attempted to expand on the research done by Weapon X, funding itself by selling successful 'products' to other nations and even some individuals and corporate interests.

The last of the Hospice guests was the mercenary known as Wade Wilson. His parting gift to Hospice was the destruction of that facility in 2011.