Super-Soldier Serum

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The Super-Soldier Serum has been regarded as one of the biggest breakthroughs in biology of the 20th century.

The intent of the serum was to induce a metagenetic event in a human not otherwise coded with the Celestial DNA markers for a metagene. As designed, it would rapidly promote a person's physical and mental capabilities to the peak of human capability in every regard.

It was developed during World War II by Dr. Abraham Erskine. Initially forced to work for Nazi Germany, the first iteration of the Super-Soldier Serum was designed to give the Third Reich warrior 'ubermensch'. One of the initial test subjects was Johann Schmidt, aka the Red Skull. Schmidt found the serum gave him significantly amplified physical ability. It also triggered paranoia and derangement, furthur destabilizing the mental state of a cold-blooded sociopath.

Erskine fled to America and joined the Super-Soldier Program in America as part of the Strategic Scientific Reserve. The serum was administered to several test subjects, notably Isaiah Bradley and Steve Rogers. Whether due to genetics, a lab accident, or some unknown potential, Steve Rogers was the only unqualified success.

Use of the serum typically produces wild muscular development and skeletal growth. Exaggeration of the adrenal glands is common and hormone production significantly increases. Virtually all test subjects after Rogers grew psychotically violent or died of heart attacks not long after the serum was administered. The project was mothballed in the 1960s, then revived for use as part of the Weapon Plus program.

The USSR pursued their own version of the serum. The Soviets developed the Infinity Formula, a weaker copy of the Super-Soldier Serum.